Quality Assesment and Comparative Analysis of the Ten Brands of Nimesulide Tablet in Kathmandu
Abstract
Background: Nimesulide, a widely used non-steroidal anti-inflammatory drug (NSAID), is prescribed for pain relief, osteoarthritis, and dysmenorrhea. Variations in manufacturing processes can result in quality differences across brands, potentially affecting efficacy and safety. This study aims to assess the pharmacopeial quality control parameters and price variation of ten brands of Nimesulide tablets available in the Nepalese market. Methods: Ten different brands of Nimesulide 100 mg tablets (five Nepalese and five Indian) were randomly selected. Quality control tests, including weight variation, hardness, friability, disintegration, dissolution, and drug content assay, were performed following British Pharmacopoeia standards. Price variation was also assessed. Results: All brands met the pharmacopeial standards for weight variation, hardness, friability, disintegration, dissolution, and drug content. Minor variations were observed in disintegration time and dissolution rates. Indian brands were relatively more expensive than Nepalese brands. Conclusion: meropenem and cephalosporins/siderophore cephalosporins have similar effectiveness as therapy for gram-negative infections in HAP .
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[20] Benet LZ. Disintegration and dissolution of tablets and capsules. Journal of Pharmacokinetics and Biopharmaceutics. 2012;40(4):251-256.
[21] Singal G, Nanda A, Kotwani A. A comparative evaluation of price and quality of some branded versus branded-generic medicines of the same manufacturer in India. Indian Journal of Pharmacology. 2011;43(2):131-136.
[22] Okoye EI, Udeala OK, Echezona AC, Onyebuchi AN. Comparative dissolution kinetics of different brands of metronidazole tablets marketed in Nigeria. Journal of Pharmacy and Allied Health Sciences. 2019;9(2):45-53.
[23] Ghosh S, Chaudhuri RK. Dissolution rate study of marketed metformin hydrochloride sustained release tablets. International Journal of Pharmaceutical Sciences and Research. 2015;6(1):168-171.
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[26] Gupta A, Shukla R, Choudhary R, Kumar A. Evaluation of quality control parameters of different brands of ibuprofen tablets available in India. Journal of Drug Delivery and Therapeutics. 2019;9(4):120-124.
[27] Shah H, Shah P, Raj S. Comparative in vitro evaluation of different brands of metformin tablets marketed in India. International Journal of Pharmaceutical and Clinical Research. 2017;9(6):432-437.
[28] Saha A, Chowdhury S, Ghosh M. Comparative analysis of the quality of metformin tablets available in Bangladesh: A dissolution profile approach. International Journal of Pharmacy and Pharmaceutical Sciences. 2014;6(8):127-131.
[29] Desai S, Agrawal S, Ray S. Comparative quality evaluation of various brands of diclofenac sodium tablets marketed in India. International Journal of Research in Pharmaceutical and Nano Sciences. 2017;6(4):155-161.
[30] Murthy M, Ravichandran V, Nagaraj K. Comparative study of marketed products of ciprofloxacin tablets: Dissolution study. International Journal of Pharmacy and Pharmaceutical Sciences. 2011;3(4):195-198.
[2] Brune K, Patrignani P. New insights into the use of currently available non-steroidal anti-inflammatory drugs. Journal of Pain Research. 2015;8:105-118.
[3] Gupta M, Kohli K, Ghaiye P. Nimesulide: Pharmacological and clinical review. Indian Journal of Pharmacology. 2008;40(1):25-29.
[4] Gupta A, Madan M, Chawla S, Arora V, Kalra S. Comparative evaluation of different brands of paracetamol tablets. International Journal of Pharmacy and Pharmaceutical Sciences. 2013;5(2):129-132.
[5] Rathore AS, Wanjari MM. Regulatory challenges for pharmaceutical products in emerging markets like Nepal: An overview. Journal of Regulatory Affairs. 2021;36(2):120-124.
[6] Patel SS, Patel NJ, Patel MS. Dissolution profile comparison of Nimesulide using various formulations. Journal of Pharmaceutical and Biomedical Analysis. 2013;53(2):136-139.
[7] Bhide MM, Nitave SA. Comparative in vitro analysis of Nimesulide tablets marketed in India. Journal of Pharmaceutical Analysis. 2020;9(4):233-238.
[8] Allen LV, Popovich NG, Ansel HC. Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems. 9th ed. Wolters Kluwer; 2011.
[9] British Pharmacopoeia Commission. British Pharmacopoeia. TSO (The Stationery Office); 2020.
[10] Mahale NB, Bhadhan PJ, Nikam KR. Comparative in vitro evaluation of the commercial Nimesulide tablets. Asian J Pharm Clin Res. 2011;2(10):2610-2612.
[11] Palanisamy S, Choudhury H, Gorain B, Chatterjee B. Comparative study on quality control and dissolution profiles of different brands of metformin tablets available in India. Indian Journal of Pharmaceutical Sciences. 2017;79(5):748-755.
[12] Ghosh S, Chowdhury S. Comparative evaluation of different marketed brands of ibuprofen tablets. International Journal of Pharmaceutical Sciences Review and Research. 2017;45(2):135-139.
[13] Aulton ME, Taylor K. Aulton's Pharmaceutics: The Design and Manufacture of Medicines. 5th ed. Elsevier; 2017.
[14] Shukla D, Chakraborty S, Singh S. Comparative analysis of quality control parameters of different brands of ciprofloxacin tablets. International Journal of Pharmaceutical Sciences Review and Research. 2018;53(3):129-135.
[15] Nisha G, Malviya R. Evaluation of pharmaceutical properties and dissolution profile of different brands of diclofenac sodium tablets available in the Indian market. International Journal of Pharmaceutical Sciences and Research. 2014;5(7):2817-2821.
[16] Rai A, Yadav A. Formulation and evaluation of tablets: A comparative study of different brands of metformin hydrochloride. Journal of Drug Delivery and Therapeutics. 2019;9(1):122-127.
[17] Huma SN, Dilshad SN. Comparative study of four different brands of ranitidine available in Karachi. Modern Chemistry & Applications. 2014;2(2):1-4.
[18] Kanfer I, Reif S, Walker RB. Dissolution kinetics of paracetamol tablets using different dissolution apparatuses. Journal of Pharmaceutical Sciences. 1995;84(10):1171-1175.
[19] Kaur T, Gill B, Kumar S, Gupta GD. Evaluation of quality control parameters on various brands of commercial paracetamol tablets. International Journal of Pharmacy and Pharmaceutical Sciences. 2011;3(3):1-5.
[20] Benet LZ. Disintegration and dissolution of tablets and capsules. Journal of Pharmacokinetics and Biopharmaceutics. 2012;40(4):251-256.
[21] Singal G, Nanda A, Kotwani A. A comparative evaluation of price and quality of some branded versus branded-generic medicines of the same manufacturer in India. Indian Journal of Pharmacology. 2011;43(2):131-136.
[22] Okoye EI, Udeala OK, Echezona AC, Onyebuchi AN. Comparative dissolution kinetics of different brands of metronidazole tablets marketed in Nigeria. Journal of Pharmacy and Allied Health Sciences. 2019;9(2):45-53.
[23] Ghosh S, Chaudhuri RK. Dissolution rate study of marketed metformin hydrochloride sustained release tablets. International Journal of Pharmaceutical Sciences and Research. 2015;6(1):168-171.
[24] Santovena A, García M, Guerra JA, Escobar C. Dissolution test of pharmaceutical tablets: A statistical comparison of dissolution profiles. Journal of Pharmacy and Pharmacology. 2003;55(8):1041-1045.
[25] Odeniyi MA, Adegoke OA, Adereti RB, Odeku OA, Itiola OA. Comparative analysis of eight brands of sulfadoxine-pyrimethamine tablets. Trop J Pharm Res. 2003;2(1):161-167.
[26] Gupta A, Shukla R, Choudhary R, Kumar A. Evaluation of quality control parameters of different brands of ibuprofen tablets available in India. Journal of Drug Delivery and Therapeutics. 2019;9(4):120-124.
[27] Shah H, Shah P, Raj S. Comparative in vitro evaluation of different brands of metformin tablets marketed in India. International Journal of Pharmaceutical and Clinical Research. 2017;9(6):432-437.
[28] Saha A, Chowdhury S, Ghosh M. Comparative analysis of the quality of metformin tablets available in Bangladesh: A dissolution profile approach. International Journal of Pharmacy and Pharmaceutical Sciences. 2014;6(8):127-131.
[29] Desai S, Agrawal S, Ray S. Comparative quality evaluation of various brands of diclofenac sodium tablets marketed in India. International Journal of Research in Pharmaceutical and Nano Sciences. 2017;6(4):155-161.
[30] Murthy M, Ravichandran V, Nagaraj K. Comparative study of marketed products of ciprofloxacin tablets: Dissolution study. International Journal of Pharmacy and Pharmaceutical Sciences. 2011;3(4):195-198.
| Files | ||
| Issue | Vol 10 No 3 (2024) | |
| Section | Original Article(s) | |
| Keywords | ||
| Nimesulide Quality Control Weight Variation Dissolution | ||
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How to Cite
1.
Musalman A. Quality Assesment and Comparative Analysis of the Ten Brands of Nimesulide Tablet in Kathmandu. JPPM. 2025;10(3).
