Tehran University of Medical Sciences Journal of Pharmacoeconomics and Pharmaceutical Management 2383-4498 3 3/4 2019 06 10 54 63 Majid Davari Department of Pharmacoeconomics and Pharmaceutical Administration, Pharmaceutical Management and Economics Research Center, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Monireh Afzali Department of Pharmacoeconomics and Pharmaceutical Administration, Pharmaceutical Management and Economics Research Center, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Mansoure Sabbagh-Bani-Azad Department of Pharmacoeconomics and Pharmaceutical Administration, Pharmaceutical Management and Economics Research Center, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Zahra Sharif Department of Pharmacoeconomy & Administrative Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Fatemeh Hadizadeh Deputy of Research and Technology, Isfahan University of Medical Sciences, Isfahan, Iran. Parisa Mirmoghtadaee Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Seyyed Mostafa Hoseini Medical Image and Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Asghar Bakrani Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Farzaneh Kolahdouzan Medical Image and Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 2018 12 30 2019 06 10 Background: There are several types of radiotherapy devices available for the treatment of cancer tumors. The present study aimed to evaluate the effectiveness of selected radiosurgery devices on the treatment of cancer tumors and Arteriovenous Malformations (AVM). Methods: The evaluation was performed in two steps; First, evaluating the effectiveness of CyberKnife, Gamma knife and Linear Accelerator (Linac) on various biological systems. Then, we compered the effectiveness of devices with each other. A systematic review was conducted in MEDLINE, EMBASE, CRD, NHSEED and Cochrane library databases. The search strategy was limited to clinical trials with less than 5 treatment sessions. All searches were conducted on December 21, 2014. Results: In total, 81 studies have been included to the review. Based on the obtained results of comparison between the reported percentages of local control rate, the safety and accuracy of CyberKnife and linac are higher than Gamma Knife. Conclusion: Our findings suggested that CyberKnife is not only more effective to cover various types of tumors in the whole body, but also is safer and easier to use for various tumors, as well as AVM treatment. https://jppm.tums.ac.ir/index.php/jppm/article/view/98 https://jppm.tums.ac.ir/index.php/jppm/article/download/98/51