Tehran University of Medical Sciences Journal of Pharmacoeconomics and Pharmaceutical Management 2383-4498 3 1/2 2018 12 08 12 16 EN Iraj Zareban Associate Professor, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Maryam Seraji Assistant Professor, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Davood Shojaeezadeh Department of Health Education and Health Promotion Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Fatemeh Rakhshani Department of Health Education and Health Promotion Department, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2017 07 04 2018 11 24 Background: Since identifying different aspects of well-being and its relationship with quality of life of the patients affected by chronic kidney disease is a very important issue, this study aims at considering the relationship between well-being and quality of life in hemodialysis patients referring to Zahedan University of Medical Sciences’ affiliated hospitals in 2016. Methods: In this descriptive analytic study, population included all individuals who referred regularity to hemodialysis section of Zahedan hospitals (129 Patients). As our data-gathering instruments, we used two questionnaires: a well-being questionnaire and a kidney disease quality of life (KDQOL) questionnaire. The data were analyzed using independent t-test, ANOVA, and Pearson correlation coefficient through SPSS v. 19. Results: The patients’ mean score of well-being was 138.95± 21.9 and their mean score of quality of life was 43.62± 6.38. According to the findings of this study, there was a reverse correlation between emotional aspect and limitation of emotional role, but their relationship was statistically significant (p= 0.02, r= -0.27); there was a statistically significant relationship between social aspect and social performance (p= 0.04, r= 0.24); there was a statistically significant relationship between mental aspect and social performance (p= 0.004, r= 0.32); there was a reverse correlation between emotional aspect and burden of kidney disease, but their relationship was statistically significant (p= 0.012, r= -0.28); similarly, there was a reverse correlation between physical aspect and burden of kidney disease, but the relationship between them was statistically significant (p= 0.03, r= -0.20). Moreover, the relationship between spiritual aspect and sexual performance was statistically significant (p= 0.05, r= 0.22).  The relationship between mental aspect and sexual performance as well (p= 0.03, r= 0.25). Conclusion: The results revealed that there is a relationship between different aspects of Well-being and quality of life of the hemodialysis patients. Therefore, paying enough attention to these patients’ needs can have positive consequences and promote their quality of life; finally, we will experience a decrease in their death rate and treatment costs. https://jppm.tums.ac.ir/index.php/jppm/article/view/33 https://jppm.tums.ac.ir/index.php/jppm/article/download/33/43