Tehran University of Medical Sciences Journal of Pharmacoeconomics and Pharmaceutical Management 2383-4498 11 1 2025 09 26 34 44 Bibin W Annai JKK Sampoorani Ammal College of pharmacy, Nmakkal, Tamil Nadu, India Divika S Annai JKK Sampoorani Ammal College of pharmacy, Nmakkal, Tamil Nadu, India Kishankanth P Annai JKK Sampoorani Ammal College of pharmacy, Nmakkal, Tamil Nadu, India Aswin A V Annai JKK Sampoorani Ammal College of pharmacy, Nmakkal, Tamil Nadu, India 2025 02 17 2025 04 24 A B S T R A C T Background:  Chronic venous illness is one of the major developing illnesses across the world. Varicose vein leads to major negative consequences, including missed work, pain, discomfort, and a deterioration in quality of life. Methods:  Varicose veins affect people’s quality of life and range in incidence from 10% to 30% worldwide Varicose vein treatment options are taken based on a number of factors, including patient preferences, postoperative risk, cost, and the degree of the venous insufficiency.). Varicose vein patients who are asymptomatic are initially treated conservatively with medications, compression therapy, and lifestyle changes. Patients who are symptomatic, on the other hand, are advised to look at surgical options such as radiofrequency ablation(RFA), endovenous laser ablation (EVLA), high ligation and stripping (HL/S) of the incompetent great saphenous vein (GSV), Cure conservatrice et Hemodynamique de Insufficience veineuse en Ambulatoire (CHIVA) , mechanochemical ablation (MOCA) , cyanoacrylate embolization (CAE),etc. Results: Each treatment is effective in the treatment of each type and each stage of varicose veins and has its pros and cons. This article analysis the varicose vein treatments and discusses the safety, efficacy and success rate of each treatments. https://jppm.tums.ac.ir/index.php/jppm/article/view/248 https://jppm.tums.ac.ir/index.php/jppm/article/download/248/168